Principal Scientist (2-year contract)
Our client is seeking a dynamic and passionate senior scientist to join a multidisciplinary team.
Role Overview:
As a Principal Scientist, you will spearhead our upstream process development for recombinant protein production. This is a fantastic opportunity to influence both scientific direction and team growth over a 24-month contract.
Key Responsibilities:
*Lead the charge in upstream process development, focusing on recombinant protein production.
*Provide scientific leadership and technical guidance to team members and project teams.
*Translate expression optimisation from shake flasks to bioreactors as the technical lead.
*Design and refine expression methods to enhance protein quality.
*Investigate how expression conditions affect protein quality attributes across key projects.
*Collaborate across functions to drive overall process improvements.
*Champion optimisations in upstream processes using a data-led approach.
*Ensure compliance with company HSE policies while working safely.
Essential Qualifications:
*Post Doc or equivalent experience in Biotechnology, Microbiology, or related disciplines.
*8+ years of hands-on experience in upstream bioprocessing with expertise in:
- Recombinant protein expression (bacterial, insect, yeast, or plant systems).
- Working with bioreactors and transferring shake flask processes into bioreactors.
- Protein purification methods and techniques.
*Strong troubleshooting and innovative problem-solving abilities.
*Comprehensive understanding of how upstream decisions impact downstream processing outcomes.
*Excellent communication skills to present complex concepts clearly.
Desirable Experience:
*Knowledge of construct design and its impact on protein expression.
*Familiarity with AI tools for experimental design.
*Experience with Ambr250 micro bioreactor systems.
*Background in protein characterisation to validate protein quality.
*Experience with scalable bioprocess technologies, such as Tangential Flow Filtration (TFF).
*Industry experience in Biopharma, AgriTech, or related sectors.
Why Join them?
At their organisation, you’ll not only be part of an innovative team but also enjoy a range of fantastic perks:
*On-the-job training to enhance your skills.
*A large campus environment fostering collaboration.
*Excellent onsite facilities, including a site restaurant, gym, and a variety of fitness classes.