Senior Scientist (DMPK)
12-month FTC
Cambridge
A leading biotech organisation is seeking a Senior Scientist with DMPK expertise to support oncology-focused discovery programs. You will develop fit-for-purpose DMPK strategies, generate and interpret ADME/PK data, and work closely with internal project teams and external CRO partners to drive decision-making across project stages.
Key Responsibilities
*Develop and evolve an appropriate DMPK screening cascade aligned to project stage and objectives.
*Design, execute and interpret in vitro ADME assays, communicating results clearly to project team members.
*Oversee CRO activities including compound submissions, experiment tracking, and timely communication of data updates.
*Prepare and maintain slide decks and documentation summarising CRO outputs and project progress; manage purchase orders and invoicing related to CRO work.
*Maintain accurate, complete and up-to-date electronic laboratory notebooks in line with internal standards.
*Perform LC-MS/MS analyses for small and large molecules, including routine maintenance and basic troubleshooting.
Key Requirements
*PhD or BSc/MSc with relevant experience in a life sciences discipline, plus industrial drug discovery experience.
*Practical knowledge of in vitro ADME assays including microsomal stability, hepatocyte stability, protein binding and permeability.
*Experience using Phoenix WinNonlin.
*Knowledge and prior experience of metabolite identification.
*Strong time management, excellent written and verbal communication skills, and the ability to build effective relationships with internal and external partners.
*Experience advancing discovery programs from Lead Optimisation (LO) through candidate selection.
*Knowledge of PK-PD and/or PBPK modelling and human dose prediction.
*Practical experience in bioanalysis by LC-MS/MS.
*Experience with MassLynx and/or UNIFI.
Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy.